DefenCELL® is the most comprehensive and advanced nutrigenomically-active supplement available. Containing both EnduraCell® and GliSODin® as well as host of other cytoprotective micronutrients, DefenCELL® is an ideal daily supplement. Think of DefenCELL® as a ‘Nutrigenomic Multi-Nutrient Formulation’.
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The unique formulation of DefenCELL® contains enzyme-active broccoli sprouts with a patented strain of French cantaloupe, produced for its high levels of antioxidant enzymes. These plant ingredients, both with significant nutrigenomic potential, are combined with selected micronutrients to activate and support the body’s natural cellular detoxification processes, cell-protective and antioxidant defences.
Serving Type: Vegetable Cellulose Capsule (suitable for vegetarians).
Clinical data shows that compounds in DefenCELL® may:
Taking the recommended four capsules of DefenCELL® daily provides:
Each Size ‘0’ DefenCELL® VegeCap® contains:
100% Whole Broccoli Sprout Powder Brassica oleracea var. italica (EnduraCell®) 250 mg; Cucumis melo juice powder 831 mcg eqv. Cucumis melo fresh fruit flesh 831 mg; Chromic chloride hexahydrate 515 mcg eqv. Chromium 100 mcg; Selenomethionine 15.625 mcg eqv. Selenium 6.25 mcg; Zinc amino acid chelate 12.5 mg eqv. Zinc 2.5 mg; Manganese amino acid chelate 12.5 mg eqv. Manganese 1.25 mg; Borax 250 mcg eqv. Boron 28.35 mcg; Molybdenum trioxide 14.92 mcg eqv. Molybdenum 10 mcg; Potassium iodide 32.7 mcg eqv. Iodine 25 mcg eqv. Potassium 7.7 mcg; Tocopherols concentrate – mixed (low-alpha type) 3.9 mg; Calcium ascorbate 7.5 mg eqv. Ascorbic acid 6.18 mg; Calcium pantothenate 10.92 mg eqv. Pantothenic acid 10 mg; Nicotinamide 10 mg; Riboflavin sodium phosphate 6.58 mg eqv. Riboflavin 5.0 mg; Thiamine hydrochloride 6.25 mg eqv. Thiamine 5.57 mg; Pyridoxal-5-phosphate 2.9 mg eqv. Pyridoxine 2.0 mg; Retinol acetate 37.95 mcg eqv. Vitamin A (RE) 33 mcg; Calcium folinate 54.02 mcg eqv. Folinic acid 50 mcg; Levomefolate calcium 54.2 mcg eqv. Levomefolic acid 50 mcg; Biotin 10 mcg; Colecalciferol (Vitamin D3) 6.25mcg (250IU); Mecobalamin (co-methylcobalamin) (Vitamin B12) 12.5 mcg
NOTE: Cell-Logic EnduraCell® is hydroganically grown in a carefully controlled environment to maximise bioactivity. Our hydroganic growing process does not use any herbicides, pesticides or other harmful chemicals. DefenCELL® is GMO free.
Adults: Two capsules twice daily with water.
Application notes: Very occasionally, adverse effects have been reported after ingestion of either fresh broccoli sprouts or supplements manufactured from fresh sprouts. These effects are typically gastrointestinal in nature and may include nausea, bloating, gastro-abdominal discomfort, and diarrhoea. The skin as an organ of elimination may also be temporarily impacted, together with neural function which is sensitive to redox-inflammation imbalances. The limited data available seem to indicate that gastro-intestinal effects are generally limited to those with pre-existing conditions and in particular to those with dysbiosis associated with a perturbed gut ecosystem.
Dose Titration: In sensitive individuals experiencing any of the aforementioned concerns, titration up to a full dose from a low starting dose allows progressive correction of the underlying causes without overloading the patient’s ability to adapt. The goal is to enable the patient to tolerate the full sulforaphane dose at a pace that eliminates symptoms whilst simultaneously restoring homeostasis.
Instructions for Dose Titration:
1. Discontinue all source of SFN – cruciferous vegetables, broccoli sprout powder and/or capsules.
2. Assuming symptoms abate, resume SFN at a very small dose. This dose may be as little as will fit on the tip of a sharp vegetable knife blade. EnduraCell® powder is the best option, although capsules can be opened.
3. Take this dose daily for a few days to ensure that the gastrointestinal system feels comfortable.
4. Gradually increase the dose by taking a second similar dose each day.
5. Repeat the process by increasing a little each day, monitoring symptoms to determine daily dose.
6. Typically, within 2 weeks, the standard recommended dose will not produce significant ill effects. In severe cases, tolerance may take weeks more to achieve. Be guided by the patient’s response.
7. Those with known dysbiosis or other gastrointestinal issues will typically find that these symptoms have either partially or fully cleared. Cruciferous vegetables can be re-introduced at this stage.
8. Where a patient has been intolerant to other foods, their introduction can be trialled one at a time.
Store below 30°C
Caution: Not recommended for coeliac patients due to the presence of 8.3 mg gliadin per recommended daily dosage. Gliadin is essential to the nutrigenomic mechanism, activating
the expression of the primary antioxidant enzymes, SOD, GPx and Cat and of the anti-inflammatory cytokine, IL-10.
Direct-acting antioxidants
When mega-doses of direct-acting antioxidants are consumed, the cell may become saturated, masking the pro-oxidant signals the cell needs to defend itself via Nrf2. Unless there is deficiency, vitamin C and any other direct-acting antioxidant supplements like A, E, beta-carotene & NAC, will inhibit the cell’s ability to upregulate its own antioxidant, detoxification
and other cytoprotective genes. If needed at all, antioxidant supplements should be reduced to quantities no greater than RDI levels found in a plant rich diet.
Cancer and treatments
Chemotherapy and Radiation: Because cancer cells ‘hijack’ the cell’s defence mechanisms, it is unknown whether SFN, GliSODin or other protective plant molecules in normal cells might also increase a cancer cell’s ability to protect itself. It is therefore advisable to avoid prescribing SFN, GliSODin and other concentrated plant extracts in those diagnosed with cancer – or undergoing treatments such as chemotherapy and radiation.
Anti-coagulant medications
The RDI for Vitamin K1 is 700 mcg. A mature broccoli vegetable contains 85 mcg of Vit K1. The Vitamin K1 content of broccoli sprouts is low in comparison, with one 700 mg capsule of EnduraCell® BioActive containing approximately 7 mcg of Vitamin K1. While Vitamin K2 appears not to interfere with coagulation, it is recommended that the patient’s clinician be consulted to prescription of GFC.
Goitrogens and thyroid function
Broccoli sprouts do not contain any significant goitrogens as found in the mature broccoli vegetable, so there are no contraindications to prescribing Cell-Logic’s broccoli sprout formulae in thyroid conditions.
1. Harman, D. Origin and evolution of the free radical theory of aging: a brief personal history, 1954 – 2009. Biogerontology. 2009: 10;773-781
2. Bjelakovic, G et al. Mortality in Randomized Trials of Antioxidant Supplements for Primary and Secondary Prevention: Systematic Review and Meta-analysis JAMA. 2007;297:842-857
3. Peregrin T The New Frontier of Nutrition Science: Nutrigenomics JADA. 2001;101(11):1306
4. Kaput J et al The case for strategic international alliances to harness nutritional genomics for public and personal health. Br J Nutri. 2005 Nov;94(5):623-32.
5. Fenech MF Dietary reference values of individual micronutrients and nutriomes for genome damage prevention: current status and road map to the future. Am J Clin Nutr. 2010 MAy;91(5):14385-14545.
6. Fenech M. Nutritional treatment of genome instability: a paradigm shift in disease prevention and in the setting of recommended dietary allowances. Nutr Res Rev 2003;16:109-22
7. Cloarec M et al. GloSODin, a vegetal SOD with gliadin as preventive against atherosclerosis Eur Ann Allergy Clin Immunol 2007 Feb;39(2):45-50.
8. Fenech M. The Genome Health Clinic and Genome Health Nutrigenomics concepts Mutagenesis 2005; 20(4): 255-269.
9. Riedl MA et al. Oral sulforaphane increases Phase II antioxidant enzymes in human airways Clin Immunol. 2009 Mar; 130(3):244-51.
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