Sulforaphane: Its “Coming of Age” as a Clinically Relevant Nutraceutical in the Prevention and Treatment of Chronic Disease

Cell-Logic, Sulforaphane: Its “Coming of Age” as a Clinically Relevant Nutraceutical in the Prevention and Treatment of Chronic Disease

Abstract: A growing awareness of the mechanisms by which phytochemicals can influence upstream endogenous cellular defence processes has led to intensified research into their potential relevance in the prevention and treatment of disease. Pharmaceutical medicine has historically looked to plants as sources of the starting materials for drug development; however, the focus of nutraceutical medicine […]

Sulforaphane and Other Nutrigenomic Nrf2 Activators: can the Clinician’s Expectation Be Matched by the Reality?

Cell-Logic, Sulforaphane and Other Nutrigenomic Nrf2 Activators: can the Clinician’s Expectation Be Matched by the Reality?

Abstract: The recognition that food-derived nonnutrient molecules can modulate gene expression to influence intracellular molecular mechanisms has seen the emergence of the fields of nutrigenomics and nutrigenetics. The aim of this review is to describe the properties of nutrigenomic activators of transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2), comparing the potential for sulforaphane […]

EnduraCell® – Understanding Nutrigenomic Therapy in the ASD Patient

Cell-Logic, EnduraCell® – Understanding Nutrigenomic Therapy in the ASD Patient

Background The specific cause or causes of Autism Spectrum Disorder remain unknown, although there are several theories which try to explain its more frequent occurrence in recent years. For parents whose children are inexplicably affected by this condition, there is much distress accompanied by an endless search for treatments which will help their child. Potential […]

Sulforaphane treatment of autism spectrum disorder (ASD)

Cell-Logic, Sulforaphane treatment of autism spectrum disorder (ASD)

Abstract: Autism spectrum disorder (ASD), encompassing impaired communication and social interaction, and repetitive stereotypic behavior and language, affects 1–2% of predominantly male individuals and is an enormous medical and economic problem for which there is no documented, mechanism-based treatment. In a placebo-controlled, randomized, double-blind clinical trial, daily oral administration for 18 wk of the phytochemical […]

Sulforaphane: translational research from laboratory bench to clinic

Cell-Logic, COVID-19 fallout

Abstract: Cruciferous vegetables are widely acknowledged to provide chemopreventive benefits in humans, but they are not generally consumed at levels that effect significant change in biomarkers of health. Because consumers have embraced the notion that dietary supplements may prevent disease, this review considers whether an appropriately validated sulforaphane-yielding broccoli sprout supplement may deliver clinical benefit. […]

Cruciferous vegetables and thyroid functions

Cell-Logic, Cruciferous vegetables and thyroid functions

Background Information For many years, it has been known that compounds called goitrogens can interfere with the normal function of the thyroid gland, preventing the incorporation of iodine into the hormones the thyroid gland produces. Such goitrogenic compounds are found in certain cruciferous vegetables. This has led to widespread confusion because it has been assumed […]

Molecular basis for chemoprevention by sulforaphane: a comprehensive review

Cell-Logic, Molecular basis for chemoprevention by sulforaphane: a comprehensive review

Abstract: The consumption of cruciferous vegetables has long been associated with a reduced risk in the occurrence of cancer at various sites, including the prostate, lung, breast and colon. This protective effect is attributed to isothiocyanates present in these vegetables, and sulforaphane (SF), present in broccoli, is by far the most extensively studied to uncover […]

Broccoli sprouts: An exceptionally rich source of inducers of enzymes that protect against chemical carcinogens

Cell-Logic, Broccoli sprouts: An exceptionally rich source of inducers of enzymes that protect against chemical carcinogens

Abstract: Induction of phase 2 detoxication enzymes [e.g., glutathione transferases, epoxide hydrolase, NAD(P)H:quinone reductase, and glucuronosyltransferases] is a powerful strategy for achieving protection against carcinogenesis, mutagenesis, and other forms of toxicity of electrophiles and reactive forms of oxygen. Since consumption of large quantities of fruit and vegetables is associated with a striking reduction in the […]